Clinical Research Infrastructure

A Clinical Research
Engine Built
For Impact.

Linden helps research teams generate novel questions, structure evidence review, and produce publication-ready outputs with oversight at every stage.

Join WaitlistSee How It Works
Manuscript Draft
Methods section complete
Evidence Chain
Wilding et al.
2021RCT
Jastreboff et al.
2022RCT
Garvey et al.
2022RCT
Review Protocol
Active
Search strategy defined
Inclusion criteria set
Screening in progress
Data extraction
PRISMA Flow
2,847 identified
423 screened
12 included
Built and used by researchers at
Harvard Medical SchoolDuke University School of MedicineUniversity of PittsburghCarnegie Mellon UniversityCornell UniversityUC BerkeleyGoogle DeepMindMicrosoftMerckEmerson Health
How Linden Works

From Research Ideation to
Publication-Ready Output, Automated.

00

Ideation

Move from broad clinical interests, datasets, or problems to novel and high-impact research questions. Rapidly explore and prioritize many candidate ideas before formal evidence review begins.

GLP-1 agonists in non-diabetic obesity: cardiovascular outcomes?High
SGLT2 inhibitors for CKD progression in elderly populations?High
Perioperative corticosteroids in elective joint replacement?Med
12 more candidates generated
01

Search

Import and organize evidence from PubMed, Cochrane, EMBASE, and uploaded collections. Define structured review criteria and build the search space.

PubMed
1,847 records
Cochrane
612 records
EMBASE
388 records
Total: 2,847 records identified
02

Screen

Run title and abstract screening with clear inclusion and exclusion criteria, reviewer assignment, and tracked rationale for every decision.

RCT, adult population, primary endpoint matchInclude
Pediatric cohort, no control groupExclude
Conference abstract only, insufficient dataExclude
Retrospective analysis, relevant populationPending
03

Review

Perform full-text review with human checkpoints, disagreement resolution, and audit-ready decision history at every stage.

Include: Relevant RCT, meets all criteria
Reviewer A: Include · Reviewer B: Include
Exclude: Wrong comparator
Reviewer A: Exclude · Reviewer B: Exclude
Disagreement: Awaiting adjudication
Reviewer A: Include · Reviewer B: Exclude
04

Extract

Capture study characteristics, outcomes, risk of bias, and structured evidence fields into reusable extraction forms.

Study designDouble-blind RCT
Sample size1,961 participants
Primary outcome% body weight change
Risk of biasLow
05

Synthesize

Generate PRISMA diagrams, evidence tables, structured summaries, publication-ready outputs and manuscript drafts that remain linked to source material.

PRISMA Diagram
Evidence Table
Forest Plot
Structured Summary
Research Workflow

Enables Seamless Control and
Review at Every Stage.

PRISMA 2020 Flow Diagram
Live
Step 0Select a topic
Generate research questions
15 candidate questions prioritized
Step 1: SearchReview search string
2,847 records
PubMed, Cochrane, EMBASE
Step 2: ScreenReview criteria
423
Title and abstract screened
Step 3: ReviewReview selected studies
89
Full-text assessed for eligibility
Step 4: ExtractReview extracted data
24
Studies with data extracted
Step 5: Synthesize
12 studies included
PRISMA diagram, evidence tables, publication-ready outputs

Every stage follows PRISMA 2020 guidelines. Human review checkpoints at screening and full-text assessment. Complete audit trails for reproducibility.

Research Outputs

Publication-Ready,
Every Figure Traceable.

PRISMA 2020 Flow Diagram
Live
Forest Plot
Wilding 2021
Jastreboff 2022
Garvey 2022
Overall
Evidence Table
Wilding1,961-14.9%
Jastreboff2,539-20.9%
Garvey803-17.4%
PRISMA Flow
Auto-generated, updates in real-time
Forest Plot
Publication-ready with effect sizes
Evidence Table
Structured for supplementary materials
Summary
Citation-linked synthesis
Citation Export
BibTeX, RIS, EndNote formats
Who Uses Linden

Research Teams Across
Medicine and Life Sciences.

Academic medical centers

Faculty & Physicians

Unlock the full potential of your clinical and research data. Turn existing datasets and clinical knowledge into higher-leverage scholarly output without compromising rigor.

Publication-quality evidence generation within real clinical schedules.

Medical schools

Medical Students

Iterate over hundreds of research ideas with autonomous agent teams. Help students and trainees explore, refine, and advance many projects efficiently through structured execution.

Rapid ideation and research training at scale across cohorts.

Payers & health systems

Healthcare Organizations

Evidence synthesis for coverage decisions and clinical pathways. Documentation that meets HTA standards.

Audit-ready outputs for formulary and policy decisions.

R&D, medical affairs & regulatory

Biotech & Pharma

Support regulatory submissions and publication planning with traceable evidence review.

Literature reviews structured for regulatory dossiers.

Methodology

Reviewable Work,
Organized From the Start.

AI should help researchers work faster, not replace their judgment. Every feature is built around this principle.

Human decisions, always

AI assists and suggests. Humans review and decide. Every screening decision, every extraction, every synthesis requires explicit approval.

Full audit trail

Every action logged. Every decision traceable. Every output links back to its source. Your review is reproducible by design.

Standards first

Workflows follow PRISMA 2020 guidelines. Built-in support for Cochrane RoB 2, GRADE, and Newcastle-Ottawa Scale.

Standards

Industry-recognized frameworks

PRISMA 2020
Reporting
Cochrane Handbook
Methods
GRADE
Quality
RoB 2
Bias

Technical whitepaper available on request.

AI Transparency

Models are built on peer-reviewed literature, but always review output material before finalizing studies.

Get Started

From Search to Submission,
In One Place.

Join research teams at leading institutions. Literature review to publication-ready outputs, organized from the start.